Effect of cholecystokinin octapeptide on food intake in pigs

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Effect of cholecystokinin octapeptide on food intake in pigs.

Considerable interest has been aroused by the suggestion that the gut hormone cholecystokinin (CCK) is released during feeding and then acts as a satiety signal (Gibbs et al. 1973). Many studies, in species ranging from the mouse to man, have shown that peripheral administration of CCK, or its octapeptide, will reduce food intake. However, inhibition of feeding could be produced via a satiety s...

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C-terminal octapeptide of cholecystokinin decreases food intake in man.

In comparison with a saline infusion, the infusion of the C-terminal octapeptide of cholecystokinin (4 ng/kg/min) decreased food intake by an average of 122 g in a group of 12 lean men without objective evidence of untoward side effects. Shapes of the cumulative intake curves under the two conditions were similar, but subjects ate less and stopped eating sooner when receiving octapeptide than w...

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Effect of glycomacropeptide fractions on cholecystokinin and food intake.

Glycomacropeptide (GMP) is the hydrophilic 64-amino acid C-terminal glycopeptide released into cheese whey when kappa-casein is cleaved by chymosin. GMP exists as a mixture of different glycoforms due to the carbohydrates sialic acid (N-acetylneuraminic acid, NeuNAc), galactose (Gal), galactosamine and glucosamine attached by O-glycosidic linkages. GMP reportedly stimulates the release of chole...

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Effect of octapeptide of cholecystokinin on canine pyloric pressure.

ISENBERG, JON I., AND ATTILA CSENDES. Efect of octapeptide of cholecystokinin on canine pyloric pressure. Am. J. Physiol. 222(2) : 42843 1. 1972.-Intraluminal pressure was measured in five dogs with gastric and duodenal cannulas. Open-tipped perfused tubes were used as pressure sensors. To localize the pylorus (i.e., gastroduodenal junction), transluminal potential difference was recorded. The ...

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Cholecystokinin octapeptide immunization: effect on growth of barrows and gilts.

A study was conducted to validate the previously reported growth response to cholecystokinin octapeptide (CCK-8) immunization in barrows and was extended to include gilts. Group-penned barrows and gilts were used to represent conditions in the swine industry. Thirty-two animals, 19 barrows and 13 gilts, were randomly assigned by sex to four pens and two treatments. The control groups were immun...

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ژورنال

عنوان ژورنال: Proceedings of the Nutrition Society

سال: 1982

ISSN: 0029-6651,1475-2719

DOI: 10.1079/pns19820020